Datatable was not designed to handle very large datasets. All operations take place on the client side. The async data example is intended to show how you can fetch data asynchronously. This solution does not support full server-side support

You could handle data filtering yourself at the moment - it is enough for search input to query the API for the appropriate data and replace it in the Datatable. It will be more difficult to handle pagination. You would have to hide the default pagination, create your own, and ensure that it loads new data into the Datatable when the page changes.

We are currently working on a product that will provide the ability to handle large amounts of data, including server-side sorting, server-side data filtering, server-side pagination and many other solutions that are not supported in Datatable.